Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Identifieur interne : 005655 ( Main/Exploration ); précédent : 005654; suivant : 005656Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Auteurs : C. Schwab [Canada] ; A J Demaggio ; N. Ghoshal ; L I Binder ; J. Kuret ; P L McgeerSource :
- Neurobiology of aging [ 0197-4580 ]
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Amyotrophic Lateral Sclerosis (metabolism), Amyotrophic Lateral Sclerosis (pathology), Antibody Specificity, Brain (enzymology), Brain (pathology), Casein Kinases, Female, Humans, Immunohistochemistry, Inclusion Bodies (chemistry), Inclusion Bodies (enzymology), Lewy Bodies (chemistry), Lewy Bodies (enzymology), Male, Middle Aged, Neurodegenerative Diseases (metabolism), Neurodegenerative Diseases (pathology), Neurofibrillary Tangles (chemistry), Neurofibrillary Tangles (enzymology), Neuroglia (chemistry), Neuroglia (enzymology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Protein Kinases (analysis), Protein Kinases (immunology), Protein Kinases (metabolism), tau Proteins (analysis), tau Proteins (immunology), tau Proteins (metabolism).
- MESH :
- chemical , analysis : Protein Kinases, tau Proteins.
- chemical , immunology : Protein Kinases, tau Proteins.
- chemical , metabolism : Protein Kinases, tau Proteins.
- chemical : Casein Kinases.
- chemistry : Inclusion Bodies, Lewy Bodies, Neurofibrillary Tangles, Neuroglia.
- enzymology : Brain, Inclusion Bodies, Lewy Bodies, Neurofibrillary Tangles, Neuroglia.
- metabolism : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases, Parkinson Disease.
- pathology : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, Neurodegenerative Diseases, Parkinson Disease.
- Aged, Aged, 80 and over, Antibody Specificity, Female, Humans, Immunohistochemistry, Male, Middle Aged.
Abstract
The distribution of casein kinase 1 delta (Cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Cki delta was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and "skein"-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Cki delta and its apparent substrate tau suggests a function for Cki delta in the abnormal processing of tau.
PubMed: 10924763
Affiliations:
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Ghoshal</name></author><author><name sortKey="Binder, L I" sort="Binder, L I" uniqKey="Binder L" first="L I" last="Binder">L I Binder</name></author><author><name sortKey="Kuret, J" sort="Kuret, J" uniqKey="Kuret J" first="J" last="Kuret">J. Kuret</name></author><author><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P L" last="Mcgeer">P L Mcgeer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2000 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:10924763</idno><idno type="pmid">10924763</idno><idno type="wicri:Area/PubMed/Corpus">001635</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001635</idno><idno type="wicri:Area/PubMed/Curation">001635</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001635</idno><idno type="wicri:Area/PubMed/Checkpoint">001635</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001635</idno><idno type="wicri:Area/Ncbi/Merge">000112</idno><idno type="wicri:Area/Ncbi/Curation">000112</idno><idno type="wicri:Area/Ncbi/Checkpoint">000112</idno><idno type="wicri:doubleKey">0197-4580::Schwab C:casein:kinase:delta</idno><idno type="wicri:Area/Main/Merge">006072</idno><idno type="wicri:Area/Main/Curation">005655</idno><idno type="wicri:Area/Main/Exploration">005655</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.</title><author><name sortKey="Schwab, C" sort="Schwab, C" uniqKey="Schwab C" first="C" last="Schwab">C. Schwab</name><affiliation wicri:level="1"><nlm:affiliation>Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, B.C, Canada. cschwab@interchange.ubc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, B.C</wicri:regionArea><wicri:noRegion>B.C</wicri:noRegion></affiliation></author><author><name sortKey="Demaggio, A J" sort="Demaggio, A J" uniqKey="Demaggio A" first="A J" last="Demaggio">A J Demaggio</name></author><author><name sortKey="Ghoshal, N" sort="Ghoshal, N" uniqKey="Ghoshal N" first="N" last="Ghoshal">N. Ghoshal</name></author><author><name sortKey="Binder, L I" sort="Binder, L I" uniqKey="Binder L" first="L I" last="Binder">L I Binder</name></author><author><name sortKey="Kuret, J" sort="Kuret, J" uniqKey="Kuret J" first="J" last="Kuret">J. Kuret</name></author><author><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P L" last="Mcgeer">P L Mcgeer</name></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="ISSN">0197-4580</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (metabolism)</term><term>Alzheimer Disease (pathology)</term><term>Amyotrophic Lateral Sclerosis (metabolism)</term><term>Amyotrophic Lateral Sclerosis (pathology)</term><term>Antibody Specificity</term><term>Brain (enzymology)</term><term>Brain (pathology)</term><term>Casein Kinases</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Inclusion Bodies (chemistry)</term><term>Inclusion Bodies (enzymology)</term><term>Lewy Bodies (chemistry)</term><term>Lewy Bodies (enzymology)</term><term>Male</term><term>Middle Aged</term><term>Neurodegenerative Diseases (metabolism)</term><term>Neurodegenerative Diseases (pathology)</term><term>Neurofibrillary Tangles (chemistry)</term><term>Neurofibrillary Tangles (enzymology)</term><term>Neuroglia (chemistry)</term><term>Neuroglia (enzymology)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Protein Kinases (analysis)</term><term>Protein Kinases (immunology)</term><term>Protein Kinases (metabolism)</term><term>tau Proteins (analysis)</term><term>tau Proteins (immunology)</term><term>tau Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Protein Kinases</term><term>tau Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Protein Kinases</term><term>tau Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Protein Kinases</term><term>tau Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Casein Kinases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Inclusion Bodies</term><term>Lewy Bodies</term><term>Neurofibrillary Tangles</term><term>Neuroglia</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Brain</term><term>Inclusion Bodies</term><term>Lewy Bodies</term><term>Neurofibrillary Tangles</term><term>Neuroglia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term><term>Amyotrophic Lateral Sclerosis</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term><term>Amyotrophic Lateral Sclerosis</term><term>Brain</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antibody Specificity</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The distribution of casein kinase 1 delta (Cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Cki delta was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and "skein"-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Cki delta and its apparent substrate tau suggests a function for Cki delta in the abnormal processing of tau.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Binder, L I" sort="Binder, L I" uniqKey="Binder L" first="L I" last="Binder">L I Binder</name><name sortKey="Demaggio, A J" sort="Demaggio, A J" uniqKey="Demaggio A" first="A J" last="Demaggio">A J Demaggio</name><name sortKey="Ghoshal, N" sort="Ghoshal, N" uniqKey="Ghoshal N" first="N" last="Ghoshal">N. Ghoshal</name><name sortKey="Kuret, J" sort="Kuret, J" uniqKey="Kuret J" first="J" last="Kuret">J. Kuret</name><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P L" last="Mcgeer">P L Mcgeer</name></noCountry><country name="Canada"><noRegion><name sortKey="Schwab, C" sort="Schwab, C" uniqKey="Schwab C" first="C" last="Schwab">C. 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